Antibacterial thymol derivatives isolated from Centipeda minima.

نویسندگان

  • Hengxing Liang
  • Fukai Bao
  • Xiaoping Dong
  • Rui Tan
  • Caijun Zhang
  • Qing Lu
  • Yongxian Cheng
چکیده

Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-beta-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature. The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.

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عنوان ژورنال:
  • Molecules

دوره 12 8  شماره 

صفحات  -

تاریخ انتشار 2007